17402-83-4, Benzo[b]thiophen-4-amine is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(d) 71.4 g (0.2 mol) of compound (IV), 122 g (1.2 mol, 6 ep) of triethylamine, and 860 ml of dichloromethane were placed in a flask and stirred at 20¡ãC for 1 hour.A mixture of 55 g (0.48 mol, 2.4 ep) of methanesulfonyl chloride and 50 ml of chloroform was added dropwise, and the addition was completed for 3 hours. After completion of the dropwise addition, the reaction was stirred at 30¡ãC for 6 hours.After the disappearance of the compound (IV) raw material, 28.3 g of compound (II) was added.(0.19 mol, 0.95 ep), the reaction was warmed at reflux and the reaction was carried out for 8 hours.After the reaction is completed, cool to room temperature and add 100mlX3 water to wash.The polyester and the organic phase were dried over anhydrous sodium sulfate, suction-filtered, and concentrated. Ethyl acetate (400 ml) was added to the residue, and the mixture was stirred and dissolved. The crystal was crystallized at room temperature for 3 hours, and then cooled to 0¡ã C. and crystallized for 3 hours.It was suction filtered, rinsed with cold ethyl acetate and sucked dry to give a white solid: crude ipripiprazole (I). The crude product was dissolved in 400 ml of anhydrous ethanol, and hydrochloric acid was added dropwise at 20¡ã C., adjusting the pH to 2 and stirring for 1 hour. After cooling to 0¡ãC, the crystals were stirred for 4 hours. Filtering, rinsing with cold ethanol, and draining. The obtained hydrochloride was dissolved in 320 ml of purified water, and 10percent sodium carbonate solution was added dropwise at 20¡ãC. The pH was adjusted to 9. The addition was complete, and the mixture was stirred for 30 minutes. The retest pH was 9 and the mixture was stirred for 30 minutes. 100ml of water was rinsed, drained, and dried white solid 70g, yield 80.5percent.
17402-83-4 Benzo[b]thiophen-4-amine 298484, abenzothiophene compound, is more and more widely used in various.
Reference£º
Patent; Zhejiang Liaoyuan Pharmaceutical Co., Ltd.; Song Zhigang; Yang Minhua; Cui Jianfeng; Chen Weijun; (16 pag.)CN106831739; (2017); A;,
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