With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6314-28-9,Benzo[b]thiophene-2-carboxylic acid,as a common compound, the synthetic route is as follows.
To a solution of Lambda/1-((3S)-4-{[(2-chloro-4-fluorophenyl)sulfonyl]amino}-3- hydroxybutyl)-L-leucinamide (67 mg, 0.15 mmol) in dichloromethane (2 mL) was added benzothiophene carboxylic acid (29 mg, 0.18 mmol) and HOOBt (2.0 mg, 0.01 mmol) at rt. After cooling the reaction mixture in an ice-bath, NMM (0.45 mmol) and EDCHCI (34 mg, 0.18 mmol) were added. After stirring overnight at rt, the reaction mixture was washed with 10 % (w/w) aqueous citric acid solution (1 mL) and brine. The organic solution was dried over MgSO4, concentrated under reduced pressure, and then purified by silica gel column chromatography (30% – 90% EtOAc/Hex) to give the title compound (0.06Og, 71%, white solid); LCMS: [MH]+= 570.2.
The synthetic route of 6314-28-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/30761; (2007); A2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem