With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.
General procedure: Representative Procedure for Mukaiyama Aldol Reactions of Me2C C(OMe)OSiMe3 with Aryl Aldehydes Catalyzed by 1-5. To an oven-dried 10-mL vial equipped with a magnetic stirring bar and a septum was added acetonitrile (5 mL), 1 (0.03 mmol), and aldehyde (1.0 mmol). The mixture was stirred for 30 min at room temperature, followed by addition of Me2C C(OMe)OSiMe3 (1.2 mmol). When the reaction was judged to be complete by TLC, the reaction was quenched by adding 2 N HCl (3 mL) solution followed by stirring the reaction mixture for an additional 3 h at room temperature. The reaction mixture was extracted with methylene chloride and dried over Na2SO4, the solution was filtered and dried on a rotavap apparatus, and then the crude product was purified by silica gel column chromatography (EtOAc:hexanes = 1:9).
As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.
Reference£º
Article; Kim, So Han; Yoon, Sungwoo; Kim, Youngjo; Verkade, John G.; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 189; (2014); p. 1193 – 1206;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem