With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.
A mixture of benzo[b]thiophen-3(2H)-one-1,1-dioxide(1b)(0.91 g, 5.0 mmol), hexamethylenetetramine (1.40 g, 10.0 mmol) and ammoniumacetate (0.95 g, 12.3 mmol) in a mixture of acetic acid (20 mL) with triuoroacetic acid (5 mL) was heated under reflux for 1 h with stirring. Aftercooling a white precipitate was ltered off and crystallised from acetic acidgiving 2b (0.74 g, 75%) as a whitepowder, mp 245C. 1H NMR (CDCl3, 400 MHz): 2.70 (s, 2H),4.02 and 4.59 (AB-syst, 2J=20.2Hz, 4H), 7.70 (d, 3J=7.2Hz, 2H), 7.78 (t, 3J=7.2Hz, 2H), 7.80 (t, 3J=7.2Hz, 2H), 7.80 (d, 3J=7.2Hz, 2H). 13C NMR (CDCl3, 100.56 MHz): 21.1, 55.9, 59.8,122.0, 124.4, 133.2, 133.7, 134.6, 141.6, 159.5. IR (film) 1318, 1464, 1664 cm-1. MS (+ESI) m/z (relative intensity) 399 ([M+H]+100). Anal. Calcd. for C19H14N2O4S2¡Á CH3COOH: C, 55.01; H, 3.95; N, 6.11. Found: C, 55.36; H, 3.67; N,6.20. The 1H NMR spectrum was in accordance with described in the literature.
1127-35-1 Benzo[b]thiophene-3(2H)-one 1,1-Dioxide 70780, abenzothiophene compound, is more and more widely used in various.
Reference£º
Article; Cekavicus, Brigita; Vigante, Brigita; Rucins, Martins; Plotniece, Aiva; Pajuste, Karlis; Petrova, Marina; Belyakov, Sergey; Duburs, Gunars; Sobolev, Arkadij; Tetrahedron Letters; vol. 55; 33; (2014); p. 4601 – 4604;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem