With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4521-30-6,Benzo[b]thiophen-2-amine,as a common compound, the synthetic route is as follows.
Preparation 1 To a stirred solution of 2-aminobenzo[b]thiophene (1.11 g) in anhydrous toluene (4.5 ml) was added carbon disulfide (0.62 g) and triethylamine (0.755 g) successively. The solution was then stirred at 0-5 C. for 3 days under nitrogen gas atmosphere. The precipitate was collected by filtration and was washed with anhydrous toluene (10 ml). The obtained white powder was dissolved in chloroform (4.5 ml), treated with triethylamine (0.76 g), and cooled to 0 C. To this solution was added dropwise ethyl chloroformate (0.84 g) over a period of 20 minutes. After being stirred at ambient temperature for one hour, the solution was washed twice with 1N hydrochloric acid (5 ml), and brine, and dried. The solvent was evaporated under reduced pressure and the residue was subjected to column chromatography on silica gel, eluted with n-hexane to give benzo[b]thiophene-2-isothiocyanate (118 mg) as an oil. IR (Neat): 2080 cm-1 NMR (CDCl3, delta): 7.06 (1H, s), 7.32-7.41 (2H, m), 7.63-7.73 (2H, m)
The synthetic route of 4521-30-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Fujisiwa Pharmaceutical Co., Ltd.; US4857513; (1989); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem