With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35212-85-2,Methyl 3-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.
EXAMPLE 62 3-(Dimethylaminomethyleneamino)benzo[b]thiophene-2-carboxylic acid methyl ester A mixture of 3.38 g (16.32 mmol) of methyl 3-aminobenzo[b]thiophene-2-carboxylate (J. Org. Chem. 37, 3224 (1972)) in 8 mL of N,N,-dimethylformamide dimethyl acetal is heated at reflux temperature for 2 hours, then cooled to room temperature. The solid is collected by filtration, washing with hexane and ethyl acetate to provide 3.96 g (93%) of a white solid, mp 73-74 C. 1H-NMR (DMSO-d6): delta 3.06 (s, 6H), 3.75 (s, 3H), 7.47 (t, 1H), 7.50 (t, 1H), 7.78 (d, 1H), 7,82-7.89 (m, 2H).
35212-85-2 Methyl 3-aminobenzo[b]thiophene-2-carboxylate 874720, abenzothiophene compound, is more and more widely used in various.
Reference£º
Patent; American Home Products Corporation; US2001/51620; (2001); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem