With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35212-85-2,Methyl 3-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.
A suspension of 3-amino-benzo[b]thiophene-2-carboxylic acid methyl ester (1.03 g, 5.0 mmol) and chloroformamidine hydrochloride (800 mg, 7.0 mmol) in diglyme (8 mL) were heated at 160 C. for 1 h. The resulting suspension was cooled to rt and filtered, and the collected solid was suction dried to give the title compound (1.14 g, 90%). 1H NMR (DMSO-d6): 8.06 (d, J=7.9 Hz, 1H), 7.89 (d, J=8.1 Hz, 1H), 7.73-7.47 (m, 2H), 7.45-7.39 (m, 1H), 7.38-7.33 (m, 1H), 7.18 (s, 0.6H), 7.05 (s, 0.6H), 6.92 (s, 0.6H).
As the paragraph descriping shows that 35212-85-2 is playing an increasingly important role.
Reference£º
Patent; Chavez, Frank; Curtis, Michael P.; Edwards, James P.; Gomez, Laurent; Grice, Cheryl A.; Kearney, Aaron M.; Savall, Brad M.; US2008/15200; (2008); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem