With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.154650-81-4,Benzo[b]thiophene-6-carbonitrile,as a common compound, the synthetic route is as follows.
A mixture of compound B-199 (2.6 g, 16 mmol) in 4N hydrochloric acid (30 mL) was stirred at 100 C for 5 hours. On completion, the reaction mixture was cooled to 0 C, and the solid was collected by filtration. The residue was dried in vacuo to give compound B-200 (2.4 g, 83% yield) as a yellow solid.
As the paragraph descriping shows that 154650-81-4 is playing an increasingly important role.
Reference£º
Patent; FORUM PHARMACEUTICALS, INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66371; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem